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KMID : 0381219860180030250
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Journal of RIMSK
1986 Volume.18 No. 3 p.250 ~ p.255
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The Acute Effects of Calcium Channel Blocker on Severe Hypertension
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Abstract
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The effects and safety of using oral nifedipine 10-20 mg as an acute antihypertensive regimen were studied in 25 consecutive patients with very high blood pressure requiring emergent reduction.
Oral nifedipine significantly reduced systolic and diastolic blood pressures in 22 patients (88%). Significant reduction of blood pressure was observed as early as 23 minutes after administration (from 226±31/133±27 mmHg to 162±19/97±16 mmHg, p<0.001). The maximal reduction of blood pressure was observed at 57 minutes after administration (from 226±31/ 133±27 mmHg to 147±25 mmHg, p<0.001). The mean action duration of nifedipine was 172±55 minutes. Significant side effects of nifedipine were reflex tachycardia(16%), and dizziness (8%).
Nifedipine is a simple, effective and safe alternative agent for managing hypertensive emergencies.
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